Is Mycobacterium tuberculosis infection life long?

Latent Mycobacterium tuberculosis Infection.

To the Editor: In their review article, Getahun et al. (May 28 issue)1 provide a useful overview of issues surrounding latent tuberculosis infection. However, newly published data regarding the performance of the T-SPOT.TB assay call into question the supposition that false conversions and reversions are more common with interferon-γ release assays (IGRAs) than with tuberculin skin tests.2 Spec...

Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses.

The primary goal of this study was to determine how chronic exposure to Ag influences the functionality of Mycobacterium tuberculosis-specific T cell responses. The frequency of IFN-gamma-producing effector CD4(+) and CD8(+) T cells dynamically changed during persistent M. tuberculosis infection. CD8(+) T cells used differential effector functions during acute and chronic phases of the immune r...

Is Critical for Host Control of Chronic Mycobacterium tuberculosis Infection

Mycobacterium Tuberculosis Infection at Pacemaker Implantation Site.

Expanding clinical indications of cardiac rhythm management have led to an increased use of pacemaker implantation which is associated with increased incidence of pacemaker infections. Staphylococcus aureus and epidermidis account for the majority of pacemaker infections. Infection of implantable cardiac devices by mycobacterium species, particularly mycobacterial tuberculosis is rare. We prese...

Mycobacterium tuberculosis Infection following Kidney Transplantation

INTRODUCTION AND AIMS Post-transplant tuberculosis (TB) is a problem in successful long-term outcome of renal transplantation recipients. Our objective was to describe the pattern and risk factors of TB infection and the prognosis in our transplant recipients. PATIENTS AND METHODS This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during th...